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ferachel-pasticche-confezione-c6b903a1

24 tablets with film

Product

Ferachel forte® is a food supplement based on Sodium Iron EDTA (Ferrazone®) Vitamin C, Folic Acid, Copper, Zinc and Selenium useful in case of reduced intake or increased need for these nutrients.

Active ingredients

Iron, Copper, Zinc, Selenium, Vitamin C and Folate contribute to the normal function of the immune system. Iron contributes to the normal formation of red blood cells and hemoglobin and to the normal transport of oxygen in the body. Copper contributes to the normal transport of iron in the body. Vitamin C increases iron absorption. Folate contributes to normal hematopoiesis.

Ingredients

Iron Sodium EDTA (Ferrazone®); Bulking agents: microcrystalline cellulose, maltodextrin; Stabilizer: Polyvinylpyrrolidone; Vitamin C protected with ethylcellulose (L-ascorbic acid); Zinc gluconate; Magnesium stearate; L-selenomethionine; Coating agents: Polyvinyl alcohol, Polyethylene glycol; Copper gluconate; Anti-caking agent: Silicon dioxide; Coating agent: Talc; Dyes: Titanium Dioxide, Riboflavin; Folic acid (pteroyl-mono-glutamic acid).

How to use

We recommend taking 1 tablet a day with a glass of water.

Nutrition Facts

Daily dose(1 tablets) %NRV
Ferric Sodium
Iron
230mg
30mg
-
Vitamin C 150mg 187,5
Folic acid 400mcg 200
Copper Gluconate 1,8mg 180
Zinc Gluconade 12,5mg 125
Selenomethionine 83mcg 150,9

NRV= daily Nutrient Reference Values (Reg. EU n. 1169/2011)

Warnings

Dietary supplements are not intended as a substitute for a varied, balanced diet and a healthy lifestyle. Keep out of reach of children under three years. Do not exceed the recommended dose.

Storage

Keep tightly closed, in a cool and dry place avoiding exposure to heat sources.
Expiration date refers to unopened package properly stored.

Gluten and lactose free.

Made in Italy

ferachel-gocce-confezione-b3402750

Ferachel® drops with sodium iron EDTA (Ferrazone)

Drops 50 ml

Product

Ferachel® drops is a food supplement based on Sodium Iron EDTA (Ferrazone®) Vitamin C, Folic Acid, Copper, Zinc and Selenium useful in case of reduced intake or increased need for these nutrients.

Active ingredients

Iron contributes to the normal formation of red blood cells and hemoglobin and to the normal transport of oxygen in the body. Copper contributes to the normal transport of iron in the body. Vitamin C increases iron absorption. Folate contributes to normal hematopoiesis.

Ingredients

Aqua, Fructose, Sodium Iron EDTA (Ferrazone®), Vitamin C (L-ascorbic acid), Zinc Gluconate, acidity corrector: Citric Acid; L-Selenomethionine, Copper Gluconate, Aroma, Preservatives: Sodium Benzoate, Potassium Sorbate; Folic Acid (Pteroil-Monoglutamic Acid).

How to use

Children aged 3 years and adolescents: 1 ml per day as it is or dissolved in a glass of water or other suitable liquid (about 150 ml); Adults: 2 ml per day as it is or dissolved in a glass of water or other suitable liquid (about 150 ml).

Nutrition Facts

Valori medi Daily dose
(1 ml children)
%NRV Daily dose
(2 ml adult)
%NRV
Iron 15mg 107 30mg 214
Vitamin C 75mg 93,75 150mg 187,5
Zinc 6,25mcg 62,5 12,5mg 125
Selenium 41,5mcg 75,45 83mcg 150,9
Copper 0,9mg 90 1,8mg 180
Folic Acid 200mcg 100 400mcg 200

*NRV= daily Nutrient Reference Values (Reg. EU n. 1169/2011)

Warnings

Dietary supplements are not intended as a substitute for a varied, balanced diet and a healthy lifestyle. Keep out of reach of children under three years. Do not exceed the recommended dose.

Storage

Keep tightly closed, in a cool and dry place avoiding exposure to heat sources.
Expiration date refers to unopened package properly stored.

Gluten and lactose free.

Made in Italy

Made in Italy

gluten-free

Gluten free

lactose-free

Lactose free

iso-certificate-aad6f64b

Production plant certified ISO 9001:2015

GMP-certificate-d4ef5418

GMP certified for food supplements

When to use

1

Whenever you feel tired and fatigued
2

In case of iron or folate deficiency or increased need
3

Preconceptional period, thanks to the presence of folic acid
4

In case of abundant menstrual flow that may cause an iron deficiency
5

In women on childbearing age with an increased need for iron such as while playing sports
6

For vegans and vegetarians or people who have a low iron diet

Clinical studies

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Effetto del FeNaEDTA nell'anemia secondaria. Effetti sul valore dell'emoglobina, sul rischio cardiovascolare e sull'aderenza alla terapia
cardionefro-logo

Ferachel Forte®: THERAPEUTIC ALTERNATIVES FOR CKD PATIENTS UNRESPONSIVE TO SULFATE IRON TREATMENT
1

Role of Ferric Sodium EDTA Associated with Vitamin C, Folic acid, Copper gluconate, Zinc Gluconate and Selenomethionine Administration in Patients with Secondary Anaemia: Effects on Hemoglobin Value and Cardiovascular Risk
6

Effect of Ferric Sodium EDTA administration, in combination with vitamin C, folic acid, copper gluconate, zinc gluconate and selenomethionine, on cardiovascular risk evaluation: exploration of the HRV frequency domain
5

Efficacy and Safety of a New Formulation of Ferric Sodium EDTA Associated with Vitamin C, Folic Acid, Copper Gluconate, Zinc Gluconate and Selenomethionine Administration in Patients with Secondary Anaemia
cardionefro-logo

ROLE OF THE NEW FERACHEL FORTE FORMULATION IN PATIENTS WITH SECONDARY ANEMIA
cardionefro-logo

ANEMIA, FROM GUIDELINES TO THE NEW FRONTIER OF ORAL THERAPY
2

EFFECT OF SODIUM FE+++ EDTA (FERACHEL FORTE®) ADMINISTRATION ON CARDIOVASCULAR RISK EVALUATION: EXPLORATION OF THE HRV IN THE FREQUENCY DOMAIN
3

Fe++ EDTA administration in secondary anemia. Effects on hemoglobine value, cardiovascular risk and Adherence to Therapy
Discover more

Scientific evidences on actives

  • Akzo Nobel Functional Chemicals October 5, 2007. APPLICATION FOR THE APPROVAL OF FERRAZONE® FERRIC SODIUM EDTA AS A SOURCE OF IRON FOR USE IN THE MANUFACTURE OF PARNUTS PRODUCTS, FOOD SUPPLEMENTS AND FORTIFIED FOODS
  • World Health Organization. (2006). Guidelines on food fortification with micronutrients / edited by Lindsay Allen et al.
  • EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS); Scientific Opinion on the use of ferric sodium EDTA as a source of iron added for nutritional purposes to foods for the general population (including food supplements) and to foods for particular nutritional uses. EFSA Journal 2010;8(1):1414. [32 pp.]. doi: 10.2903/j.efsa.2010.1414
  • Evaluations of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) 2007
  • Marchitto N. et al. A pilot study on secondary anaemia in “frailty” patients treated with the Ferric Sodium EDTA in combination with vitamin C, folic acid, copper gluconate, zinc gluconate and selenomethionine: safety of treatment explored by HRV non-linear analysis as predictive factor of cardiovascular tolerability. Eur Rev Med Pharmacol Sci, 2020 in press.
  • Marchitto N. et al. Role of Ferric Sodium EDTA associated with vitamin C, folic acid, copper gluconate, zinc gluconate and selenomethionine administration in patients with secondary anaemia. Effects on hemoglobin value and cardiovascular risk. Health Sci J. 2019, 13 (5), 682.
  • Marchitto N. et al. Effect of Ferric Sodium EDTA administration, in combination with vitamin C, folic acid, copper gluconate, zinc gluconate and selenomethionine, on cardiovascular risk evaluation: exploration of the HRV frequency domain. Clinical Practice, 2019, 16(5), 1245-1251.
  • Curcio A. et al. Efficacy and Safety of a New Formulation of Ferric Sodium EDTA Associated with Vitamin C, Folic Acid, Copper Gluconate, Zinc Gluconate and Selenomethionine Administration in Patients with Secondary Anaemia. J Blood Lymph. 2018, 8: 224.
  • Alessandra Graziottin. Ferro (NaFe3+EDTA), Lattoferrina, Vitamina C e Vitamina B12: sinergie farmacologiche: Per ottimizzare prevenzione e cura dell’anemia prima, durante e dopo la gravidanza.
  • Ai Guo Ma et al. Supplementation of iron alone and combined with vitamins improves haematological status, erythrocyte membrane fluidity and oxidative stress in anaemic pregnant women. British Journal of Nutrition (2010), 104, 1655-1661.
  • Hallberg L. et al. The role of vitamin C in iron absorption. Int J Vitam Nutr Res Suppl. 1989;30:103-8.
  • Reeves P.G. et al. Dietary Copper Deficiency Reduces Iron Absorption and Duodenal-Enterocyte Hephaestin Protein in Male and Female Rats. J Nutr. 2005, 135(1):92-8.
  • National Institutes of Health, Office of Dietary Supplements, (2006), “Dietary Supplement Fact Sheet: Selenium,”
  • Phuong Nguyen, Ruben Grajeda, PaulMelgar, JessicaMarcinkevage,Rafael Flores ,Usha Ramakrishnan, and Reynaldo Martorell. Effect of Zinc on Efficacy of Iron Supplementation in Improving Iron and Zinc Status in Women. Journal of Nutrition and Metabolism,Volume 2012.
  • Munro I.C., SODIUM IRON EDTA, CanTox Inc., Mississauga, Ontario Canada. 796. Sodium iron EDTA (WHO Food Additives Series 32)
  • Appel, M.J.; Kuper, C.F.; Woutersen, R.A. 2001. Disposition, accumulation and toxicity of iron fed as iron (11) sulfate or as sodium iron EDTA in rats. Food Chem Toxicol 39(3):261-269.
  • Scholl, TO., 2005, Iron status during pregnancy: setting the stage for mother and infant, Am J Clin Nutr, vol. 81(5 suppl), pp. 1218S-1222S.
  • Wang, B., Siyan, Z., Yinyin, X., and Liming, L., 2008, Effect of sodium iron ethylenediaminetetra- acetate (NaFe3+EDTA) on haemoglobin and serum ferritin in iron-deficient populations: a systematic review and meta-analysis of randomised and quasi-randomised controlled trials, Br J Nutr, vol. 100, pp. 1169-1178.
  • Anupam Aditi et al. Vitamin C, Gastritis, and Gastric Disease: A Historical Review and update. Dig Dis Sci. 2012, 57:2504-2515.
  • Rodrigo R. et al. Cardioprotection against ischaemia/reperfusion by vitamins C and E plus n-3 fatty acids: molecular mechanisms and potential clinical applications. Clin Sci (Lond). 2013, 124(1):1-151968.
  • Ryszard Rutkowski et al. Vitamin C: is it time to re-evaluate its role in health and disease? Postep. Derm. Alergol. 2012; XXIX, 6: 456-460.
  • Select Committee on GRAS Substances (SCOGS) Opinion: L-ascorbic acid
  • Padayatty S.J. et al. Vitamin C pharmacokinetics: implications for oral and intravenous use. Annals of Internal Medicine 2004; 140:533-7.
  • Rumbold A, Ota E, Nagata C, Shahrook S, Crowther CA-Vitamin C supplementation in pregnancy.
  • Scheers N. Regulatory Effects of Cu, Zn, and Ca on Fe Absorption: The Intricate Play between Nutrient Transporters. Nutrients 2013, 5(3), 957-970.
  • Linee guida Ministero della salute reperibili al sito:
  • López de Romaña D. et al. Risks and benefits of copper in light of new insights of copper homeostasis. Journal of Trace Elements in Medicine and Biology, 25 (2011) pp. 3-13.
  • Select Committee on GRAS Substances (SCOGS) Opinion: Copper (cupric) sulfate
  • Hazra, A. Tripathi, S.K. Folic Acid Revisited. Indian Journal of Pharmacology, 2001,(5), pp.322-342
  • Letter Regarding Dietary Supplement Health Claim for Folic Acid With Respect to Neural Tube Defects (Docket No. 91N-100H).
  • Lumley J. et al., (2001). Periconceptional Supplementation with Folate and/or Multivitamins for Preventing Neural Tube Defects. Cochrane Database Syst.Rev 2011.
  • Weekly Iron-Folic Acid Supplementation (Wifs) in Women of Reproductive Age: its Role in Promoting Optimal Maternal and Child Health. World Health Organization 2009, Who/Nmh/Nhd/Mnm/09.2.
  • Richard D. Semba, Luigi Ferrucci, Anne R. Cappola4, Michelle O. Ricks, Amanda L. Ray, Qian-Li Xue, Jack M. Guralnik, and Linda P. Fried. Low Serum Selenium Is Associated with Anemia Among Older Women Living in the Community: The Women’s Health and Aging Studies I and II.
  • EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)
  • Select Committee on GRAS Substances (SCOGS) Opinion: Magnesium gluconate; Potassium gluconate; Sodium gluconate; Zinc gluconate.
  • Chaffee BW, King JC. Effect of zinc supplementation on pregnancy and infant outcomes: a systematic review. Paediatric and Perinatal Epidemiology. 2012, 26 (Suppl. 1):118-137.
  • WHO: e-Library of Evidence for Nutrition Actions (eLENA)
  • Andrews NC. Forging a field: the golden age of iron biology. Blood 2008; 112(2): 219–230
  • Crichton R. Inorganic Biochemistry of Iron Metabolism – From Molecular Mechanisms to Clinical Consequences. 2nd edition. England: John Wiley & Sons, Ltd.; 2001.
  • Dunn LL et al. Iron uptake and metabolism in the new millennium. Trends Cell Biol 2007;17(2): 93-100.
  • Crichton R et al. Iron Therapy With Special Emphasis on Intravenous Administration. 4th edition. London, Boston: International Medical Publishers; 2008.
  • Ovidio Brignoli Società Italiana di Medicina Generale. Anemia e terapia marziale I dati di Health Search - Società Italiana di Medicina Generale.
  • “La carenza di ferro”, di Nevin S. Scrimshaw, pubbl. su “Le Scienze (Scientific American)”, num.280, dic.1991, pag.16-22.
  • Triolo G. et al. Linee Guida per il trattamento dell’anemia nell’insufficienza renale cronica. Giornale Italiano di Nefrologia, 2003, 20, S-24, pp. S61-S82.
  • Rockey DC. Occult and obscure gastrointestinal bleeding: causes and clinical management. Nat Rev Gastroenterol Hepatol 2010;7:265-79.
  • Hershko C, Skikne B. Pathogenesis and management of iron deficiency anemia: emerging role of celiac disease, Helicobacter pylori, and autoimmune gastritis. Semin Hematol 2009;46:339-50.
  • Clark SF. Iron deficiency anemia: diagnosis and management. Curr Opin Gastroenterol 2009;25.
  • Pasricha SR, Flecknoe-Brown SC, Allen KJ, et al. Diagnosis and management of iron deficiency anaemia: a clinical update. Med J Aust 2010;193:525-32.
  • Paesano R. et al. Ipoferremia e anemia da carenza di ferro in gravidanza. Il Ginecologo, 2008, 3 (Suppl 1), pp. 1-6.
  • Van Thuy P, Berger J, Nakanishi Y, Khan NC, Lynch S, Dixon P. The use of NaFeEDTAfortified fish sauce is an effective tool for controlling iron deficiency in women of childbearing age in rural Vietnam.
  • Xiu X Han MD, Yong Y Sun, Ai G Ma, Fang Yang, Feng Z Zhang, Dian C Jiang, Yong Li. Moderate NaFeEDTA and ferrous sulfate supplementation can improve both hematologic status and oxidative stress in anemic pregnant women.
  • Saaka M. Combined Iron and Zinc Supplementation Improves Haematologic Status of Pregnant Women in Upper West Region of Ghana. Ghana Med J. 2012 Dec; 46(4): 225-233.
  • Shubhada J. Kanani,Rashmi H. Poojara. Supplementation with Iron and Folic Acid Enhances Growth in Adolescent Indian Girls. J Nutr. 2000 Feb.
  • Bier-Ulrich A.M. et al. The impact of intensive serial plasmapheresis on iron metabolism and Hb concentration in menstruating women: a prospective randomized placebo-controlled double-blind study.Transfusion 2003; 43:405-401.
  • Kapur G. et al. Iron supplementation in children with celiac disease. Indian J Pediatr. 2003 Dec;70(12):955-8.
  • Yang Y. et al. Efficacy and safety of iron supplementation for the elderly patients undergoing hip or knee surgery: a meta-analysis of randomized controlled trials. The Journal of Surgical Research 2011, 171(2):e201-7.

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Information about products on this site cannot be understood as medical advice and they do not intend, nor can, replace medical prescriptions. Information on this site relates to the ingredients and actives contained in food supplements. Supplements cannot be considered as means of treating, preventing, diagnosing or alleviating diseases. Food supplements are not substitutes of a varied and balanced diet and a healthy life style.

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